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Clinical drug monitoring

At the forefront of drug monitoring

Drug misuse often occurs unintentionally in any population, which is why we offer a broad array of drug testing for your diverse needs. Whether you are seeking to start a drug monitoring program or to supplement an existing program with additional testing, we offer urine and oral fluid drug testing to meet the needs of healthcare providers, pain specialists, behavioral health specialists, and health systems.

Our reputation in clinical laboratory diagnostics is built on an unparalleled commitment to service, coupled with our industry-leading, comprehensive drug testing portfolio, including an extensive menu for prescription drugs used in the treatment of anxiety, depression, and substance use disorders; for other controlled medications; and for substances of abuse.

With state-of-the-art technologies, fast turnaround time, easy-to-interpret results and more than 650 on-staff toxicology and medical experts, Quest Diagnostics helps you protect your patients and your practice by helping you make more informed decisions.

Insights, clinical benefits, patient compliance, and protection

Explore our provider-focused clinical drug monitoring information for primary care, pain specialists, behavioral health specialists, and health systems.

Provider information

Prescription drug monitoring: why monitor your patients?

We recognize that behind every specimen and result there is a human life—a life whose quality may be improved when pain or other controlled medications are used as you prescribed. For example, for responsible patients with refractory chronic and recurring pain, opioids not only relieve suffering, but also can support normal daily functioning, alleviate stress, and improve sleep.

Periodic urine drug testing (UDT) or oral fluid drug testing can help you to:

  • Monitor your patient treatment plan
  • Detect other nonprescribed medication(s)
  • Manage therapy safety and maintain availability for your patients by assisting with regulatory compliance
  • Test for other drugs of abuse (cocaine, methamphetamine, etc)

Controlled substance medications have been linked to diversion (passing the drug on to others for sale or use), noncompliance, and abuse. 

If you oversee patients who take pain or other controlled medications, especially those whom you suspect may be abusing these substances, how can you meet state and federal regulations yet still provide access to needed therapies?

One step you can take is proactive drug monitoring with urine drug testing (UDT) or oral fluid drug testing, which helps to:

  • Supplement patient self-reporting and usage of state Prescription Drug Monitoring Program (PDMP) information, with documented lab results
  • Identify drug compliance, diversion, or abuse

Quest Diagnostics constantly seeks innovative ways to enhance patient care and provide value to our customers. We provide tools that can help you create an efficient, reliable drug monitoring program. 


At Quest Diagnostics, our goal is to serve you in a way that supports the needs of your practice. That’s why we regularly deliver Health Trends®, a series of data-supported scientific reports that provide insights into critical healthcare issues. We provide our unique findings to empower better patient care, population health, and public policy.


Our most recent Health Trends report, Drug Misuse in America 2022: A Decade Lost to the Drug Crisis, examines more than 20 million deidentified clinical drug tests over the past 10 years.

download the report

Our comprehensive test menu covers a broad range of substances

We offer a broad menu of drug tests, including tests for prescription drugs, other controlled medications, and illicit drugs—with enhanced sensitivity to better detect benzodiazepines and opioids.

Drug / Drug Class

  • Alcohol metabolites (EtG, EtS)
  • Alcohol biomarkers (PEth)
  • Amphetamines
  • Amphetamines, with reflex to d-methamphetamine (dextromethamphetamine) and l-methamphetamine (levomethamphetamine) isomers
  • Antidepressants
  • Antipsychotics (urine)
  • Antipsychotics (serum)
  • Barbiturates
  • Benzodiazepines
  • Buprenorphine with naloxone
  • Carisoprodol
  • Cocaine metabolite
  • Eszopiclone
  • Fentanyl
  • Gabapentin
  • Heroin metabolite
  • Marijuana metabolite
  • Meperidine
  • Methadone metabolite
  • Methamphetamine d/l isomers
  • Methylphenidate
  • Mitragynine
  • Naltrexone
  • Opiates
  • Oxycodone
  • Phencyclidine
  • Pregabalin
  • Propoxyphene
  • Synthetic cannabinoids
  • Synthetic stimulants
  • Tapentadol
  • Tramadol
  • Tricyclic antidepressants
  • Zolpidem

We also offer a wide range of panels that screen for several different combinations of drugs and medications.


An interactive state-by-state overview of patient compliance and inconsistent results.

See how inconsistent drug test results compare in your state
Drug monitoring map


We work every day to bring you exceptional service and efficiency.

We offer a broad range of drug tests to identify the presence of prescribed, non-prescribed, and illicit drugs. We also provide other clinical testing services for conditions such as infectious disease and general health.

The power of Quest

Drug monitoring resource center

We offer a variety of useful resources for healthcare professionals.

Resource Center

Our toxicology experts are here for you

Whether you want to discuss test selection, sample requirements, results interpretation, or to schedule an in-depth call for more complex questions, our team is available via phone at 1.877.40.RXTOX (1.877.407.9869)

Contact us